Article

Pervasive Horizontal Transfer of Adeno-Associated Virus Capsid Genes

2025-03-17

Abstract excerpt

Adeno-associated viruses (AAVs) are non-pathogenic DNA viruses with potent gene delivery capabilities, making them essential tools in gene therapy and biomedical research. Despite their therapeutic importance, key aspects of AAV natural biology remain obscure, complicating efforts to explain rare AAV-associated diseases and optimize gene therapy vectors. By analyzing sequence data from virus isolates and endogenou...

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Literature Corpus work: 7d47f87a-e87a-54fd-b761-772d68c85aeb
DOI: 10.1101/2025.03.15.643461

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