Article

Species-specific AAVR dominates species-tropism of adeno-associated virus (AAV) vectors

2025-12-05

Abstract excerpt

<title>Abstract</title> <p>The variation in AAV vector mediated transduction between species makes it difficult to predict and translate from preclinical animal studies to clinical trials. We previously demonstrated that a 265G insertion (AAV-AM) into the AAV-LK03 primate selective capsid allows robust transduction between species. Here we demonstrate that the capsid species specificity cannot be complemented in...

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Literature Corpus work: 8a6992b0-7f88-5f79-b6f4-fc70a0719e83
DOI: 10.21203/rs.3.rs-8198480/v1

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