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Divergent engagements between adeno-associated viruses with their cellular receptor AAVR

21 Aug 2019

Abstract excerpt

Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the...

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PMID: 31434885
DOI: 10.1038/s41467-019-11668-x

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