Article

Theoretical Design and Structural Characterization of Cross-Genera AAVGo.1-HBoV3 Chimeric Capsids

2026-02-27

Abstract excerpt

Parvoviruses are small, non-enveloped DNA viruses, several of which have been adapted as vectors for gene therapy. Adeno-associated virus (AAV) is clinically established but constrained by limited genome capacity and pre-existing immunity. Human bocaviruses (HBoVs) possess larger packaging potential and airway tropism, motivating exploration of AAV-HBoV hybrid architectures. We modeled a chimeric construct (AAV-HB...

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Literature Corpus work: bd814c99-17c5-578f-b54f-c6209c8a16d3
DOI: 10.20944/preprints202602.1542.v1

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