Article

Microbial Infection Instigates Tau-Related Pathology Via Activating Neuroimmune cGAS-STING Pathway

2023-07-28

Abstract excerpt

Background: Microbial infection, the strong trigger to directly induce inflammation in brain, is long considered a risk factor of Alzheimer’s disease (AD), but how these infections contribute to neurodegeneration remains underexplored.<br><br>Methods: To examine the effect of HSV-1 infection on tauopathy in local hippocampus of P301S mice, we utilized a modified HSV-1 strain (mHSV-1) and examined the role of the i...

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Literature Corpus work: 19b50c0a-c9fd-5d02-8889-4f1fc1da13d6
DOI: 10.2139/ssrn.4522399

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