Article

Activation of innate immune cGAS-STING pathway contributes to Alzheimer’s pathogenesis in 5×FAD mice

2022-11-01

Abstract excerpt

cGAS senses microbial and host-derived double-stranded DNA (dsDNA) in cytoplasm to trigger cellular innate immune response in a STING-dependent manner. However, it remains unknown whether the cGAS-STING pathway in innate immunity contributes to Alzheimer’s disease (AD). Here we demonstrated the detectable binding of the cGAS-dsDNA in cytoplasm and the activation of microglial cGAS-STING pathway in brains of human...

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Literature Corpus work: ca23090e-a2d2-5f8f-8e6a-3ca15bb80456
DOI: 10.1101/2022.10.30.514314

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