Article
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression.
Cell reports - 17 Nov 2020
Rexach Jessica E, Polioudakis Damon, Yin Anna, Swarup Vivek, Chang Timothy S, Nguyen Tam, Sarkar Arjun, Chen Lawrence, Huang Jerry, Lin Li-Chun, Seeley William, Trojanowski John Q, Malhotra Dheeraj, Geschwind Daniel H
Abstract excerpt
To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD, and PSP. We uncover a complex temporal trajectory of microglial-immune pathways involving the type 1 interferon response associated with tau pathology in the early stages,...
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