Article

Microglial cGAS deletion protects against amyloid-β induced Alzheimer’s disease pathogenesis

2023-08-09

Abstract excerpt

Innate immune activation plays a vital role in the development of Alzheimer’s disease (AD) and related dementias (ADRD). Among which, the DNA sensing cyclic GMP-AMP synthase (cGAS)- STING pathway has been implicated in diverse aspects of AD progression. In the current study, we showed that the cGAS-STING signaling was up-regulated in AD and this elevation was mainly contributed by the microglial population other t...

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Literature Corpus work: 39a945f9-599b-500c-bc1f-0efa78991abf
DOI: 10.1101/2023.08.07.552300

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