Article

Harnessing cGAS-STING signaling to counteract the genotoxic-immune nexus in tauopathy

2025-09-28

Abstract excerpt

Tauopathies are progressive neurodegenerative disorders characterized by aberrant tau aggregation, cognitive decline, and persistent neuroinflammation, yet the mechanisms driving neuroinflammation and disease progression remain incompletely understood. Here, utilizing human postmortem AD brains and a mouse model of tauopathy, we report that genotoxic stress-induced cyclic GMP-AMP synthase (cGAS)-stimulator of inte...

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Literature Corpus work: d3640968-2e02-57d5-91f2-0db2e32d10c7
DOI: 10.1101/2025.09.27.678980

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