Article

STING-triggered CNS inflammation in human neurodegenerative diseases

2023-02-14

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Some neurodegenerative diseases have an element of neuroinflammation that is triggered by viral nucleic acids, resulting in the generation of type I interferons. In the cGAS-STING pathway, microbial and host-derived DNA bind and activate the DNA sensor cGAS, the resulting cyclic dinucleotide, 2’3-cGAMP binds to a critical adaptor protein, stimulator of interf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57d1fe33-7957-5020-98a3-fb4894dc61d3
DOI: 10.21203/rs.3.rs-2264071/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

STING-triggered CNS inflammation in human neurodegenerative diseasesDOI 10.21203/rs.3.rs-2264071/v2Read

Redox regulation of neuroinflammatory pathways contributes to damage in Alzheimer’s disease brainSemantic proximity Read

Mitophagy and cGAS–STING crosstalk in neuroinflammationSemantic proximity Read

The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseasesSemantic proximity Read

Harnessing cGAS-STING signaling to counteract the genotoxic-immune nexus in tauopathySemantic proximity Read

Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementiaSemantic proximity Read

Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in miceSemantic proximity Read

IFI204 Drives Gasdermin D–Mediated Mitochondrial Permeabilization to Amplify Neuronal Pyroptosis in Ischemic StrokeSemantic proximity Read

Mitochondrial DNA-triggered innate immune response: mechanisms and diseasesSemantic proximity Read

Microbial Infection Instigates Tau-Related Pathology Via Activating Neuroimmune cGAS-STING PathwaySemantic proximity Read

Mitochondrial DNA and Inflammation in Alzheimer’s DiseaseSemantic proximity Read

Pathophysiological Roles of the cGAS-STING Inflammatory PathwaySemantic proximity Read

cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologiesSemantic proximity Read