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Viral Infection Induces Alzheimer’s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

2025-06-15

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> The Pathogen Infection Hypothesis proposes that β-Amyloid (Aβ) functions as an antimicrobial peptide, with pathogen-induced aggregation potentially contributing to Alzheimer’s disease (AD) pathology. <h4>METHODS</h4> We used human iPSC-derived 2D neurons and 3D cerebral organoids from wild-type and familial AD ( PSEN1/2 mutant) lines to model acute infections...

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Literature Corpus work
5d899105-ef16-509e-b4a3-2ce56ec02458
DOI
10.1101/2025.06.11.659008
Open publication

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Viral Infection Induces Alzheimer’s Disease-Related Pathways and Senescence in iPSC-Derived Neuronal ModelsDOI 10.1101/2025.06.11.659008
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