Article

The modifiers that cause changes in gene essentiality

2025-03-06

Abstract excerpt

<h4>ABSTRACT</h4> The phenotype of a mutation often differs across genetically distinct individuals. In the most extreme case, a gene can be essential for viability in one genetic background, but dispensable in another. Although genetic context-dependency of mutant phenotypes is frequently observed, the underlying causes often remain elusive. Here, we investigated the genetic changes responsible for differences i...

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Literature Corpus work: 1969c2b9-6d3f-5dfc-871b-b3d7933c29be
DOI: 10.1101/2025.03.06.641712

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