Article
Resurrection from lethal knockouts: Bypass of gene essentiality.
Biochemical and biophysical research communications - 30 Jul 2020
Du Li-Lin
Abstract excerpt
Understanding genotype-phenotype relationships is a central pursuit in biology. Gene knockout generates a complete loss-of-function genotype and is a commonly used approach for probing gene functions. The most severe phenotypic consequence of gene knockout is lethality. Genes with a lethal knockout phenotype are called essential genes. Based on genome-wide knockout analyses in yeasts, up to approximately a...
Topics
- Animals
- Epistasis, Genetic
- Evolution, Molecular
- Gene Knockout Techniques
- Genes, Essential
- Genes, Fungal
- Genes, Lethal
- Genes, Synthetic
- Models, Genetic
- Phenotype
- Saccharomyces cerevisiae