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Article

Resurrection from lethal knockouts: Bypass of gene essentiality.

Biochemical and biophysical research communications - 30 Jul 2020

Du Li-Lin

Abstract excerpt

Understanding genotype-phenotype relationships is a central pursuit in biology. Gene knockout generates a complete loss-of-function genotype and is a commonly used approach for probing gene functions. The most severe phenotypic consequence of gene knockout is lethality. Genes with a lethal knockout phenotype are called essential genes. Based on genome-wide knockout analyses in yeasts, up to approximately a...

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Share to Epistasis, Genetic
Share to Gene Knockout Techniques
Share to Genes, Essential

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Genes, Lethal

Share to Genes, Synthetic

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Share to Suppression, Genetic

Source

Identifiers

PMID: 32507598
DOI: 10.1016/j.bbrc.2020.05.207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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