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Article

Genotype to phenotype: a complex problem.

Science (New York, N.Y.) - 23 Apr 2010

Dowell Robin D, Ryan Owen, Jansen An, Cheung Doris, Agarwala Sudeep, Danford Timothy, Bernstein Douglas A, Rolfe P Alexander, Heisler Lawrence E, Chin Brian, Nislow Corey, Giaever Guri, Phillips Patrick C, Fink Gerald R, Gifford David K, Boone Charles

Abstract excerpt

We generated a high-resolution whole-genome sequence and individually deleted 5100 genes in Sigma1278b, a Saccharomyces cerevisiae strain closely related to reference strain S288c. Similar to the variation between human individuals, Sigma1278b and S288c average 3.2 single-nucleotide polymorphisms per kilobase. A genome-wide comparison of deletion mutant phenotypes identified a subset of genes that were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20413493
DOI: 10.1126/science.1189015
PMCID: PMC4412269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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