Article
The modifiers that cause changes in gene essentiality.
Cell systems - 15 Apr 2026
Batté Amandine, Bosch-Guiteras Núria, Pons Carles, Ota Marina, Lopes Maykel, Sharma Sushma, Tellini Nicolò, Paltenghi Claire, Conti Michelle, Kan Kwan Ting, Ho Uyen Linh, Wiederkehr Michaël, Barraud Jonas, Ashe Mark, Aloy Patrick, Liti Gianni, Chabes Andrei, Parts Leopold, van Leeuwen Jolanda
Abstract excerpt
Mutant phenotypes often vary across genetically distinct individuals. To identify the causes of such genetic background effects, we studied differences in gene essentiality across 18 genetically diverse natural yeast strains. We identified 39 genes that were essential in the laboratory reference strain but not in at least one other genetic background, and we mapped and validated the genetic variants that were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.