Article
Loss-of-function mutation survey revealed that genes with background-dependent fitness are rare and functionally related in yeast.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2022
Caudal Elodie, Friedrich Anne, Jallet Arthur, Garin Marion, Hou Jing, Schacherer Joseph
Abstract excerpt
In natural populations, the same mutation can lead to different phenotypic outcomes due to the genetic variation that exists among individuals. Such genetic background effects are commonly observed, including in the context of many human diseases. However, systematic characterization of these effects at the species level is still lacking to date. Here, we sought to comprehensively survey background-dependent...
Topics
- Disease
- Gene Regulatory Networks
- Genetic Fitness
- Humans
- Loss of Function Mutation
- Phenotype
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins