Article

Diverse natural variants suppress mutations in hundreds of essential genes

2020-11-24

Abstract excerpt

The consequence of a mutation can be influenced by the context in which it operates. For example, loss of gene function may be tolerated in one genetic background, but lead to lethality in another. The extent to which mutant phenotypes are malleable, the complexity of the architecture of modifiers, and the identities of causal genes and pathways remain largely unknown. Here, we measure the fitness effects of ~1,50...

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Literature Corpus work: affc276a-af5d-56f2-92ca-a53779c314c9
DOI: 10.1101/2020.11.24.395855

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