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Article

The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae.

Molecular systems biology - 1 Dec 2019

Galardini Marco, Busby Bede P, Vieitez Cristina, Dunham Alistair S, Typas Athanasios, Beltrao Pedro

Abstract excerpt

Loss-of-function (LoF) mutations associated with disease do not manifest equally in different individuals. The impact of the genetic background on the consequences of LoF mutations remains poorly characterized. Here, we systematically assessed the changes in gene deletion phenotypes for 3,786 gene knockouts in four Saccharomyces cerevisiae strains and 38 conditions. We observed 18.5% of deletion phenotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31885205
DOI: 10.15252/msb.20198831
PMCID: PMC6901017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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