Article
Natural variants suppress mutations in hundreds of essential genes.
Molecular systems biology - 1 May 2021
Parts Leopold, Batté Amandine, Lopes Maykel, Yuen Michael W, Laver Meredith, San Luis Bryan-Joseph, Yue Jia-Xing, Pons Carles, Eray Elise, Aloy Patrick, Liti Gianni, van Leeuwen Jolanda
Abstract excerpt
The consequence of a mutation can be influenced by the context in which it operates. For example, loss of gene function may be tolerated in one genetic background, and lethal in another. The extent to which mutant phenotypes are malleable, the architecture of modifiers and the identities of causal genes remain largely unknown. Here, we measure the fitness effects of ~ 1,100 temperature-sensitive alleles of yeast...
Topics
- Gain of Function Mutation
- Gene Expression Regulation, Fungal
- Genes, Essential
- Genes, Modifier
- Genetic Variation
- Mutation
- Phenotype
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins