Article

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decay

2021-01-27

Abstract excerpt

The nonsense-mediated mRNA decay (NMD) pathway monitors translation termination to degrade transcripts with premature stop codons and regulate thousands of human genes. Here we show that an alternative mammalian-specific isoform of the core NMD factor UPF1, termed UPF1 LL , enables condition-dependent remodeling of NMD specificity. Previous studies indicate that the extension of a conserved regulatory loop in the...

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Literature Corpus work: 1931c6f9-829d-5eb4-ab1c-6f7fbdbefdfa
DOI: 10.1101/2021.01.27.428318

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