Article

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cells

2021-07-07

Abstract excerpt

The paralogous human proteins UPF3A and UPF3B are involved in recognizing mRNAs targeted by nonsense-mediated mRNA decay (NMD). While UPF3B has been demonstrated to support NMD, contradicting reports describe UPF3A either as an NMD activator or inhibitor. Here, we present a comprehensive functional analysis of UPF3A and UPF3B in human cells using combinatory experimental approaches. Overexpression or knockout of U...

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Literature Corpus work: 12512751-07b5-5673-bc33-c6330be8e26a
DOI: 10.1101/2021.07.07.451444

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