ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.

doi:10.1038/ncomms14021

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Article

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.

Nature communications - 23 Dec 2016

Serdar Lucas D, Whiteside DaJuan L, Baker Kristian E

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) represents a eukaryotic quality control pathway that recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of non-functional and potentially toxic truncated polypeptides. A critical component of the NMD machinery is UPF1, an RNA helicase whose ATPase activity is essential for NMD, but for which the precise function and site of action...

Topics

Adenosine Triphosphatases
Adenosine Triphosphate
Codon, Nonsense
Hydrolysis
Models, Biological
Mutation
Peptide Chain Termination, Translational
Polyribosomes
RNA Helicases
RNA Stability
RNA, Messenger
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28008922
DOI: 10.1038/ncomms14021
PMCID: PMC5196439

Genes

UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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