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Article

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.

Nature communications - 23 Dec 2016

Serdar Lucas D, Whiteside DaJuan L, Baker Kristian E

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) represents a eukaryotic quality control pathway that recognizes and rapidly degrades transcripts harbouring nonsense mutations to limit accumulation of non-functional and potentially toxic truncated polypeptides. A critical component of the NMD machinery is UPF1, an RNA helicase whose ATPase activity is essential for NMD, but for which the precise function and site of action...

Read the complete abstract on PubMed

Topics

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Share to Adenosine Triphosphatases
Share to Adenosine Triphosphate
Share to Codon, Nonsense

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrolysis

Share to Peptide Chain Termination, Translational

Share to Polyribosomes

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Source

Open in PubMed Open full text

Identifiers

PMID: 28008922
DOI: 10.1038/ncomms14021
PMCID: PMC5196439

Genes

UPF1
UPF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.PMID 28008922Read ↗

Inhibition of post-termination ribosome recycling at premature termination codons in UPF1 ATPase mutants.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.Semantic proximity Read ↗

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.Semantic proximity Read ↗

A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.Semantic proximity Read ↗

Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthroughSemantic proximity Read ↗

Characterization of the mIF4G domains in the RNA surveillance protein Upf2Semantic proximity Read ↗

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.Semantic proximity Read ↗

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Semantic proximity Read ↗

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