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Article

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.

Molecular cell - 6 Aug 2015

Lee Suzanne R, Pratt Gabriel A, Martinez Fernando J, Yeo Gene W, Lykke-Andersen Jens

Abstract excerpt

RNA quality-control pathways get rid of faulty RNAs and therefore must be able to discriminate these RNAs from those that are normal. Here we present evidence that the adenosine triphosphatase (ATPase) cycle of the SF1 helicase Upf1 is required for mRNA discrimination during nonsense-mediated decay (NMD). Mutations affecting the Upf1 ATPase cycle disrupt the mRNA selectivity of Upf1, leading to indiscriminate...

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Identifiers

PMID: 26253027
DOI: 10.1016/j.molcel.2015.06.036
PMCID: PMC4673969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cellsSemantic proximity Read ↗

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