Article

Single-cell mutation calling and phylogenetic tree reconstruction with loss and recurrence

2022-01-28

Abstract excerpt

Tumours evolve as heterogeneous populations of cells, which may be distinguished by different genomic aberrations. The resulting intra-tumour heterogeneity plays an important role in cancer patient relapse and treatment failure, so that obtaining a clear understanding of each patient’s tumour composition and evolutionary history is key for personalised therapies. Single-cell sequencing now provides the possibility...

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Literature Corpus work: d4985633-cb85-532b-84cc-8a11aef5de93
DOI: 10.1101/2022.01.28.478229

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