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Article

Single-cell mutation calling and phylogenetic tree reconstruction with loss and recurrence.

Bioinformatics (Oxford, England) - 14 Oct 2022

Kuipers Jack, Singer Jochen, Beerenwinkel Niko

Abstract excerpt

MOTIVATION: Tumours evolve as heterogeneous populations of cells, which may be distinguished by different genomic aberrations. The resulting intra-tumour heterogeneity plays an important role in cancer patient relapse and treatment failure, so that obtaining a clear understanding of each patient's tumour composition and evolutionary history is key for personalized therapies. Single-cell sequencing (SCS) now...

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PMID: 36000873
DOI: 10.1093/bioinformatics/btac577
PMCID: PMC9563700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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