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Statin Use and Genetically Predicted HMG-CoA Reductase Inhibition in Relation to Clonal Hematopoiesis

2026-07-13

Abstract excerpt

<h4>Background</h4> Clonal hematopoiesis (CH) is associated with increased risks of diverse cardiovascular diseases, hematologic malignancies and mortality, yet no preventive therapies are approved. As emerging data implicate lipid pathways in CH pathogenesis, we investigated the association of statin use and genetically proxied inhibition of HMG-CoA reductase (HMGCR) with CH risk, and validated findings using pr...

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Literature Corpus work
18d75ecb-c940-5d31-bce1-6cb935f5705c
DOI
10.64898/2026.07.08.26357595
Open publication

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