Article
Analysis of the effects of statin therapy on clonal dynamics in clonal haematopoiesis of indeterminate potential: insights from the English Longitudinal Study of Ageing
2025-04-19
Abstract excerpt
Clonal haematopoiesis of indeterminate potential (CHIP) is the acquisition of somatic mutations in leukaemia-associated genes in haematopoietic progenitors with age. It increases the risk of haematological malignancy (HM), cardiovascular disease (CVD) and mortality mediated by CHIP-associated inflammation, with larger clones posing higher risks. Statins have been found to reduce the risk of progression from myelod...
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Identifiers and source
- Literature Corpus work
- c89c0b40-3d3c-50a0-850d-1f9e6bc531a0
- DOI
- 10.1101/2025.04.15.25325668