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Article

Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study.

International journal of epidemiology - 1 Apr 2018

Orho-Melander Marju, Hindy George, Borgquist Signe, Schulz Christina-Alexandra, Manjer Jonas, Melander Olle, Stocks Tanja

Abstract excerpt

Background: It is unclear whether there are causal associations between blood lipids, statin use and cancer risks. Under certain assumptions, Mendelian randomization analysis of a genetic marker for an exposure eliminates reverse causation and confounding. Methods: We applied Mendelian randomization analysis to genetic scores, comprising 26-41 single-nucleotide polymorphisms (SNPs), as instrumental variables...

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Source

Identifiers

PMID: 29165714
DOI: 10.1093/ije/dyx237

Genes

HMGCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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