Article

Pleiotropic effects of statins on ischemic heart disease: a Mendelian Randomization study in the UK Biobank

2020-01-16

Abstract excerpt

<h4>Objectives</h4> Statins appear to have pleiotropic effects. We examined whether specifically statins, of the major lipid modifiers, operate on ischemic heart disease (IHD) via testosterone. As a validation, we assessed whether a drug that unexpectedly likely increases IHD also operates via testosterone. <h4>Design</h4> A sex-specific univariable and multivariable Mendelian randomization study <h4>Setting</h4>...

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Literature Corpus work: 7cd83065-5c09-50e7-974a-081d7af8a3f2
DOI: 10.1101/2020.01.14.20017400

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