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Article

Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.

eLife - 13 Oct 2020

Carter Paul, Vithayathil Mathew, Kar Siddhartha, Potluri Rahul, Mason Amy M, Larsson Susanna C, Burgess Stephen

Abstract excerpt

Laboratory studies have suggested oncogenic roles of lipids, as well as anticarcinogenic effects of statins. Here we assess the potential effect of statin therapy on cancer risk using evidence from human genetics. We obtained associations of lipid-related genetic variants with the risk of overall and 22 site-specific cancers for 367,703 individuals in the UK Biobank. In total, 75,037 individuals had a cancer...

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Identifiers

PMID: 33046214
DOI: 10.7554/eLife.57191
PMCID: PMC7553780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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