Article
A Mendelian Randomization Approach Using 3-HMG-Coenzyme-A Reductase Gene Variation to Evaluate the Association of Statin-Induced Low-Density Lipoprotein Cholesterol Lowering With Noncardiovascular Disease Phenotypes.
JAMA network open - 1 Jun 2021
Liu Ge, Shi Mingjian, Mosley Jonathan D, Weng Chunhua, Zhang Yanfei, Lee Ming Ta Michael, Jarvik Gail P, Hakonarson Hakon, Namjou-Khales Bahram, Sleiman Patrick, Luo Yuan, Mentch Frank, Denny Joshua C, Linton MacRae F, Wei Wei-Qi, Stein C Michael, Feng QiPing
Abstract excerpt
Importance: Observational studies suggest that statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, may be associated with beneficial effects in many noncardiovascular diseases. Objective: To construct a weighted HMG-CoA reductase (HMGCR) gene genetic risk score (GRS) using variants in the HMGCR gene affecting low-density lipoprotein cholesterol as an instrumental variable for...
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