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Article

Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: A Mendelian randomization phenome-wide association study in the UK Biobank.

British journal of clinical pharmacology - 1 Oct 2023

Pham Kitty, Mulugeta Anwar, Lumsden Amanda, Hyppӧnen Elina

Abstract excerpt

AIMS: Lipid-lowering medications are widely used to control blood cholesterol levels and manage a range of cardiovascular and lipid disorders. We aimed to explore the possible associations between LDL lowering and multiple disease outcomes or biomarkers. METHODS: We performed a Mendelian randomization phenome-wide association study (MR-PheWAS) in 337 475 UK Biobank participants to test for associations between...

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Identifiers

PMID: 37208559
DOI: 10.1111/bcp.15793
PMCID: PMC10952153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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