Article

Quantifying the pro- and antimutagenic roles of DNA damage and repair

2020-01-01

Abstract excerpt

Genome integrity is essential to the survival of any living organism. The genome is constantly challenged by a multitude of endogenous and exogenous mutagenic factors such as environmental exposures or replication errors. Therefore, evolution has supplied cells with a number of repair mechanisms to protect their genetic information; however, excessive exposures or defects in the repair machinery can lead to the ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92e0b703-6a96-5c91-a94c-db642b2d86c9
DOI: 10.17863/cam.50845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantifying the pro- and antimutagenic roles of DNA damage and repairDOI 10.17863/cam.50845Read

DNA Damage and Repair: From Molecular Mechanisms to Health ImplicationsSemantic proximity Read

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer.Semantic proximity Read

DNA damage response, genetic instability and cancer: From mechanistic insights to personalized treatmentSemantic proximity Read

Establishing Linkages Among DNA Damage, Mutagenesis, and Genetic Diseases.Semantic proximity Read

Investigating the origins of the mutational signatures in cancer.Semantic proximity Read

DNA Repair: From Genome Maintenance to Biomarker and Therapeutic TargetSemantic proximity Read

DNA Damage, Mutagenesis and CancerSemantic proximity Read

Assessment of genetic damage in healthy and diseased tissue.Semantic proximity Read

Implications of DNA damage and DNA repair on human diseasesSemantic proximity Read

DNA damage, DNA repair and disease.Semantic proximity Read

The dual nature of mismatch repair as antimutator and mutator: for better or for worseSemantic proximity Read

Endogenously generated DNA nucleobase modifications source, and significance as possible biomarkers of malignant transformation risk, and role in anticancer therapy.Semantic proximity Read