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Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair.

Cell - 28 Jan 2016

Haradhvala Nicholas J, Polak Paz, Stojanov Petar, Covington Kyle R, Shinbrot Eve, Hess Julian M, Rheinbay Esther, Kim Jaegil, Maruvka Yosef E, Braunstein Lior Z, Kamburov Atanas, Hanawalt Philip C, Wheeler David A, Koren Amnon, Lawrence Michael S, Getz Gad

Abstract excerpt

Mutational processes constantly shape the somatic genome, leading to immunity, aging, cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into these processes by the clonal expansion of the malignant cell. Here, we characterize a less explored layer of the mutational landscape of cancer: mutational asymmetries between the two DNA strands. Analyzing whole-genome sequences of 590...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26806129
DOI: 10.1016/j.cell.2015.12.050
PMCID: PMC4753048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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