Article
Establishing Linkages Among DNA Damage, Mutagenesis, and Genetic Diseases.
Chemical research in toxicology - 17 Oct 2022
Basu Ashis K, Essigmann John M
Abstract excerpt
DNA damage by chemicals, radiation, or oxidative stress leads to a mutational spectrum, which is complex because it is determined in part by lesion structure, the DNA sequence context of the lesion, lesion repair kinetics, and the type of cells in which the lesion is replicated. Accumulation of mutations may give rise to genetic diseases such as cancer and therefore understanding the process underlying...
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