Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma

Abstract excerpt

<title>Abstract</title> <p>Two APOBEC (apolipoprotein-B mRNA editing enzyme catalytic polypeptide-like) DNA cytosine deaminase enzymes (APOBEC3A and APOBEC3B) generate somatic mutations in cancer, driving tumour development and drug resistance. Here we used single cell RNA sequencing to study APOBEC3A and APOBEC3B expression in healthy and malignant mucosal epithelia, validating key observations with immunohistoc...

Topics

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• Cytidine Deaminase
• DNA Damage
• Gastric Mucosa
• Gene Expression Regulation, Neoplastic
• Minor Histocompatibility Antigens
• Mutagenesis
• Mutation
• Proteins

Identifiers and source

Literature Corpus work

188bc8ff-df44-5922-adf9-8ca5a8bb42c5

DOI

10.21203/rs.3.rs-3997426/v1