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Article

The MLL3/GRHL2 complex regulates malignant transformation and anti-tumor immunity in squamous cancer.

The Journal of experimental medicine - 7 Apr 2025

Nam Chehyun, Huang Guowei, Zheng Yueyuan, Zhao Hua, Pan Yuhao, Hu Boyan, Wenger Talia, Van Hieu T, Xu Li-Yan, Li En-Min, Koeffler H Phillip, Ge Kai, Dou Yali, Sinha Uttam K, Park Young Min, Lin De-Chen

Abstract excerpt

Upper aerodigestive squamous cell carcinoma (UASCC) presents significant challenges in clinical management due to its aggressive nature. Here, we elucidate the role of MLL3 mutations as early, clonal genomic events in UASCC tumorigenesis, highlighting their role as foundational drivers of cancer development. Utilizing CRISPR-edited, cross-species organoid modeling, we demonstrate that loss of MLL3 contributes to...

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Topics

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Share to Carcinoma, Squamous Cell
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to DNA-Binding Proteins

Share to Gene Expression Regulation, Neoplastic

Share to Histone-Lysine N-Methyltransferase

Share to Immune Checkpoint Inhibitors

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 39964485
DOI: 10.1084/jem.20240758
PMCID: PMC11834937

Genes

GRHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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