Article
APOBEC3A, not APOBEC3B, drives deaminase mutagenesis in human gastric epithelium
2024-10-31
Abstract excerpt
<h4>ABSTRACT</h4> Cancer genomes frequently carry APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like)-associated DNA mutations, suggesting APOBEC enzymes as innate mutagens during cancer initiation and evolution. However, the pure mutagenic impacts of the specific enzymes among this family that are responsible for APOBEC-associated mutagenesis remain unclear in human normal cell lineage, particularl...
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Identifiers and source
- Literature Corpus work
- b6a2f147-2672-516b-a593-7bccfff21257
- DOI
- 10.1101/2024.10.28.620744