Article

Squamous-state excursions activate APOBEC3A in cancer

2026-05-26

Abstract excerpt

<h4>SUMMARY</h4> The cytidine deaminase APOBEC3A is a major endogenous mutagen in human cancer, yet is rarely captured in bulk tumor RNA or protein profiles despite the prominent mutational scars it leaves in cancer genomes. The origin of these episodic mutational bursts has remained unclear, with prevailing models emphasizing sustained inflammatory signaling. Here, we show that APOBEC3A is induced in a rare subp...

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Literature Corpus work: 0a632a74-31d8-5ace-827c-f1e1a96dc381
DOI: 10.64898/2026.05.24.727500

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