Article
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.
Cell reports - 26 Jun 2014
Henderson Stephen, Chakravarthy Ankur, Su Xiaoping, Boshoff Chris, Fenton Tim Robert
Abstract excerpt
APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC signature mutations occur at high frequency in cervical cancers (CESC), over 99% of which are caused by human papillomavirus (HPV). We tested whether APOBEC-mediated mutagenesis is particularly important in HPV-associated tumors by comparing...
Topics
- Carcinoma, Squamous Cell
- Cell Transformation, Viral
- Class I Phosphatidylinositol 3-Kinases
- Cytidine Deaminase
- Cytosine
- Deamination
- Head and Neck Neoplasms
- Humans
- Minor Histocompatibility Antigens
- Mutation