Article
APOBEC3A drives deaminase mutagenesis in human gastric epithelium.
Genome research - 1 Oct 2025
An Yohan, Lee Ji-Hyun, Lim Joonoh, Youk Jeonghwan, Park Seongyeol, Park Ji-Hyung, Yi Kijong, Kim Taewoo, Nam Chang Hyun, Lee Won Hee, Oh Soo A, Bae Yoo Jin, Klompstra Thomas M, Lee Haeun, Han Jinju, Lee Junehwak, Park Jung Woo, Kim Jie-Hyun, Kim Hyunki, Snippert Hugo, Koo Bon-Kyoung, Ju Young Seok
Abstract excerpt
Cancer genomes frequently carry apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC)-associated DNA mutations, suggesting APOBEC enzymes as innate mutagens during cancer initiation and evolution. However, the pure mutagenic impacts of the specific enzymes among this family remain unclear in human normal cell lineages. Here, we investigate the comparative mutagenic activities of APOBEC3A and APOBEC3B,...
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