Article

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis <i>In Vivo</i>

2019-12-27

Abstract excerpt

<h4>SUMMARY</h4> The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a causal driver or inconsequential passenger to the overall tumor phenotype. We show that human APOBEC3A expression in murine colon and liver tissues increases tumorigenesis. All other APOBEC3 family members including APOBEC3B did not as strongly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52b710a5-0d22-5362-9954-9e1b94a9bea6
DOI: 10.1101/2019.12.27.889345

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis <i>In Vivo</i>DOI 10.1101/2019.12.27.889345Read

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.Semantic proximity Read

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential.Semantic proximity Read

Human APOBEC3B promotes tumor heterogeneity <i>in vivo</i> including signature mutations and metastasesSemantic proximity Read

DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In VivoSemantic proximity Read

The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancerSemantic proximity Read

Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer.Semantic proximity Read

Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases.Semantic proximity Read

APOBEC3A, not APOBEC3B, drives deaminase mutagenesis in human gastric epitheliumSemantic proximity Read

APOBEC-Induced Mutagenesis in Cancer.Semantic proximity Read

APOBEC3B, a molecular driver of mutagenesis in human cancersSemantic proximity Read

The APOBEC3A deaminase drives episodic mutagenesis in cancer cellsSemantic proximity Read

Mechanisms of APOBEC3 mutagenesis in human cancer cellsSemantic proximity Read