Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.

Molecular cell - 4 Feb 2021

Youmans Daniel T, Gooding Anne R, Dowell Robin D, Cech Thomas R

Abstract excerpt

Polycomb repressive complex 2 (PRC2) silences expression of developmental transcription factors in pluripotent stem cells by methylating lysine 27 on histone H3. Two mutually exclusive subcomplexes, PRC2.1 and PRC2.2, are defined by the set of accessory proteins bound to the core PRC2 subunits. Here we introduce separation-of-function mutations into the SUZ12 subunit of PRC2 to drive it into a PRC2.1 or 2.2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Binding Sites
Share to Chromatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Homeodomain Proteins

Share to Induced Pluripotent Stem Cells

Share to Neoplasm Proteins

Share to Polycomb Repressive Complex 2

Source

Open in PubMed Open full text

Identifiers

PMID: 33338397
DOI: 10.1016/j.molcel.2020.11.044
PMCID: PMC7867654

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.PMID 33338397Read ↗

Macromolecular interactions dictate Polycomb-mediated epigenetic repressionSemantic proximity Read ↗

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.Semantic proximity Read ↗

Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review.Semantic proximity Read ↗

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.Semantic proximity Read ↗

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.Semantic proximity Read ↗

DNA elements tether canonical Polycomb Repressive Complex 1 to human genesSemantic proximity Read ↗

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains.Semantic proximity Read ↗

Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development.Semantic proximity Read ↗

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.Semantic proximity Read ↗

Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemiaSemantic proximity Read ↗

Polycomb complexes in normal and malignant hematopoiesisSemantic proximity Read ↗

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.