Article

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targets

2020-06-05

Abstract excerpt

CpG Island promoter genes make up more than half of human genes, and a subset regulated by Polycomb-Repressive Complex 2 (PRC2 + -CGI) become DNA methylated and silenced in cancer. Here, we perform a systematic regulatory analysis of CGI genes across TCGA cancer types, finding that PRC2 + -CGI genes are frequently prone to transcriptional upregulation as well. These upregulated PRC2 + -CGI genes control importa...

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Literature Corpus work: fa0eb4d9-6d46-5d88-ab6f-8bfa05f829b0
DOI: 10.1101/2020.06.04.134858

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