Article

Effects of DNA oxidation on the evolution of genomes

2017-06-15

Abstract excerpt

Oxidation of DNA increases its mutation rate, causing otherwise rare G → T transversions during DNA replication. Here we use a comparative genomic approach to assess the importance of DNA oxidation for the evolution of genomic sequences. To do so, we study the mutational spectrum of G n -tracks on various timescales, ranging from one human generation to the divergence between primates, and compare it to the prope...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 176037b0-0c58-561a-93f5-d67b95885bbe
DOI: 10.1101/150425

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of DNA oxidation on the evolution of genomesDOI 10.1101/150425Read

Hierarchical determinants of the oxidation-induced mutational landscape in human cellsSemantic proximity Read

Contributing factors to the oxidation-induced mutational landscape in human cells.Semantic proximity Read

Linking somatic mutations in cancer to the electronic properties of DNASemantic proximity Read

Linking somatic mutations in cancer to the electronic properties of DNA.Semantic proximity Read

Signatures of Mutational Processes in Human DNA EvolutionSemantic proximity Read

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signatureSemantic proximity Read

A time-invariant principle of genome evolution.Semantic proximity Read

RNA-DNA Differences: Redox Stress, Genomic Instability, and Implications for Human HealthSemantic proximity Read

Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes.Semantic proximity Read

Human and bats genome robustness under COSMIC mutational signaturesSemantic proximity Read

Population dynamics of GC-changing mutations in humans and great apesSemantic proximity Read

Transcription induces strand-specific mutations at the 5' end of human genes.Semantic proximity Read