Article

Linking somatic mutations in cancer to the electronic properties of DNA

2026-01-02

Abstract excerpt

Oxidative stress, generated by both endogenous and exogenous agents, can cause DNA lesions that, if not repaired, accumulate as somatic mutations and can contribute to cancer initiation. Here, we explored this problem through the lens of DNA electronic properties, quantified by the vertical ionization potential (vIP) of nucleobase motifs, which reflects their susceptibility to oxidation. We analyzed genome-wide ex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8685b10e-62b0-5f18-80d6-0db9f4f0c8e0
DOI: 10.64898/2026.01.02.697387

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Linking somatic mutations in cancer to the electronic properties of DNADOI 10.64898/2026.01.02.697387Read

Linking somatic mutations in cancer to the electronic properties of DNA.Semantic proximity Read

Genomic landscape of oxidative DNA damage and repair reveals regioselective protection from mutagenesisSemantic proximity Read

The interplay of mutations and electronic properties in disease-related genes.Semantic proximity Read

Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells.Semantic proximity Read

The Repertoire of Mutational Signatures in Human CancerSemantic proximity Read

DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification.Semantic proximity Read

Investigating the origins of the mutational signatures in cancer.Semantic proximity Read

Motif-Centered Analyses Reveal Universal and Tissue-Specific Mutagenic Mechanisms Operating in the Human BodySemantic proximity Read

Methods and applications of genome-wide profiling of DNA damage and rare mutations.Semantic proximity Read

Mutational impact and signature of ionizing radiationSemantic proximity Read

Assessment of genetic damage in healthy and diseased tissue.Semantic proximity Read

Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cellsSemantic proximity Read