Article
Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes.
Nucleic acids research - 26 May 2015
Bacolla Albino, Zhu Xiao, Chen Hanning, Howells Katy, Cooper David N, Vasquez Karen M
Abstract excerpt
Single base substitutions (SBSs) and insertions/deletions are critical for generating population diversity and can lead both to inherited disease and cancer. Whereas on a genome-wide scale SBSs are influenced by cellular factors, on a fine scale SBSs are influenced by the local DNA sequence-context, although the role of flanking sequence is often unclear. Herein, we used bioinformatics, molecular dynamics and...
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