Article

Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature

2025-09-01

Abstract excerpt

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and are therefore expected to differ across cell types with distinct exposures to mutagens, division rates, and cellular programs. Yet when mutations in humans are decomposed into a set of “signatures”, one single base substitution signature, SBS5, is present across cell types and tissues, and predominates in po...

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Identifiers and source

Literature Corpus work: e9101fdb-3376-5965-9167-a6d7ca00d76f
DOI: 10.1101/2025.08.28.672844

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