Article
A time-invariant principle of genome evolution.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010
De Subhajyoti, Babu M Madan
Abstract excerpt
Uncovering general principles of genome evolution that are time-invariant and that operate in germ and somatic cells has implications for genome-wide association studies (GWAS), gene therapy, and disease genomics. Here we investigate the relationship between structural alterations (e.g., insertions and deletions) and single-nucleotide substitutions by comparing the following genomes that diverged at different...
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