Article

RNA-DNA Differences: Redox Stress, Genomic Instability, and Implications for Human Health

2025-03-03

Abstract excerpt

RNA-DNA differences (RDDs) challenge the traditional view of RNA as a faithful copy of DNA, arising through RNA editing, transcriptional errors, and oxidative damage. Reactive oxygen species (ROS) play a central role, inducing lesions like 8-oxo-guanine that compromise transcription and translation, leading to dysfunctional proteins. This review explores the biochemical basis of RDDs, their exacerbation under oxid...

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Literature Corpus work: 28377793-0edf-531d-b7fb-00649a6da6dc
DOI: 10.20944/preprints202503.0163.v1

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